The influence of phorbol myristic acetate on the formation of pseudopodia and phagosomes of macrophages.

Prayitno, Adi (2002) The influence of phorbol myristic acetate on the formation of pseudopodia and phagosomes of macrophages.

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Abstract

The immunity against infectious agent is mainly mediated and performed by the T cells and macrophages. Protein kinase C performs a very important role in carrying out cellular activity. Phorbol ester is knawn as a tumor promoter and is competitive with diacyl glycerol to activate protein kinase C. The pseudopodia is being a mobility of the cell. Phagosomes are the membrane bound intracellular vesicle which contain phagocytozed material. The objective of the study is to find out the difference of the length of pseudopodia and the number of complete phagosomes of BALB/c mice macrophages after the administration of phorbol myristic acetate.In this experiment the culture of peritoneal macrophage derived from BALB/c mice are treated with phorbol myristic acetate at various concentration varying from 5 ng/ml to 100 ng/ml for as long as 10 minutes then the C. albicans is added. The pseudopodia and the number of complete phagosome are observed after 30 minute. The experimental design is factorial and orthogonal polynomial. The data consisting of the lenght of pseudopodia and the number of complete phagosome are analyzed applying the One Way Anova to show the differences of each manipulation. The result of this experiment indicates, that the differences dealing with the length of pseudopodia and the number of complete phagosome at various concentration of phorbol myristic acetate are statistically significant (p

Item Type: Article
Subjects: Collections > Koleksi Perpustakaan Di Indonesia > Perpustakaan Di Indonesia > JKPTYARSI > Journal > Kedokteran > Jurnal Kedokteran YARSI > Tahun 2001
Divisions: Universitas Komputer Indonesia > Perpustakaan UNIKOM
Depositing User: M.Kom Taryana Suryana
Date Deposited: 16 Nov 2016 07:38
Last Modified: 16 Nov 2016 07:38
URI: http://repository.unikom.ac.id/id/eprint/3184

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